ANGIOLOK ® 80
Telmisartan Tablets USP 80mg
Mechanism of Action
Telmisartan is an angiotensin-II receptor antagonist with antihypertensive activity due mainly to selective blockade of angiotensin-II receptors and the consequent reduced pressor effect of angiotensin II.
Telmisartan is rapidly absorbed from the gastrointestinal tract; the absolute oral bioavailability is dose dependent and is about 42% after a 40 mg dose and 58% after a 160-mg dose. Peak plasma concentrations of telmisartan are reached about 0.5 to 1 hour after an oral dose. Telmisartan is over 99% bound to plasma proteins. It is excreted almost entirely in the faeces via bile, mainly as unchanged drug. The terminal elimination half-life of telmisartan is about 24 hours.
- It is indicated for the treatment of hypertension.
- It is indicated in the treatment of heart failure
- It is indicated for prevention of cardiovascular events in patients with established atherosclerotic cardiovascular disease, or type 2 diabetes mellitus with target-organ damage.
Side effects are usually mild. Symptomatic hypotension including dizziness may occur, particularly in patients with intravascular volume depletion. Hyperkalemia occurs occasionally;
Dosage and Administration
Telmisartan is administered orally.
Hypertension: usually 40mg once daily (but 20mg may be sufficient), increased if necessary after at least 4 weeks, to max 80mg once daily
Prevention of cardiovascular events, 80mg once daily
20-40 mg once daily in mild or moderate impairment; avoid in severe impairment or biliary obstruction.
20mg mg once daily in severe impairment
Store below 30C in a dry place. Protect from light. Keep medicine out of reach of children.
3 × 10 Alu-Alu Blister